Th17 Book

TH17 Cells in Health and Disease

Editor: Shuiping Jiang

Publisher: Springer New York

Hardcover, 536 p. 38 illus. 29 in color 

ISBN: 978-1-4419-9370-0

June 2011. $169.00

Book website:

TH17 book.jpg

Table of Contents:

Part One: The Immunology of IL-17 Family and TH17 Cells

Chapter 1 From Th1/Th2 paradigm to Th17 cells: Le roi est mort, vive le roi
Amit Awasthi and Vijay K Kuchroo, Harvard University, USA 

Chapter 2 Th17 cytokines: characteristics, regulation, and biological function
Pornpimon Angkasekwinai and Chen Dong, University of Texas and MD Anderson Cancer Center, USA 

Chapter 3 TGF-beta and Th17 cells
Samuel Huber, Enric Esplugues, Richard Flavell, Yale University, USA 

Chapter 4 IL-6: a pleiotropic cytokine and Th17 cells
Akihiro Kimura, Tetsuji Naka and Tadamitsu Kishimoto, Osaka University, Japan 

Chapter 5 Apoptosis and Th17 cell differentiation
J. Magarian Blander, Mount Sinai School of Medicine, USA 

Chapter 6 IL-1 and innate immunity in the differentiation of Th17 cells
Stephen J. Lalor, Caroline E. Sutton and Kingston H.G. Mills, Trinity College, Ireland 

Chapter 7 Negative regulation of Th17 differentiation
Mark S. Sundrud and Sergei Koralov, Harvard University, USA 

Chapter 8 Signal transduction in Th17 cell differentiation
Xiang-Ping Yang, John J. O’Shea, Kamran Ghoreschi and Arian Laurence, National Institutes of Health, USA 

Chapter 9 Structure and IL-17 receptor signaling
Michael Tsang and Sarah L. Gaffen, University of Pittsburgh, USA 

Chapter 10 Trafficking receptors and migration of Th17 cell subsets
Chang H. Kim, Purdue University, USA 

Chapter 11 Plastic T cells: Recycling effector functions?
Eleftherios I. Agorogiannis, Stephen P. Cobbold and Herman Waldmann, University of Oxford, UK    

Part Two: TH17 Cells in Health and Disease

Chapter 12 Human Th17 cells
Francesco Annunziato, Lorenzo Cosmi, Francesco Liotta, Enrico Maggi and Sergio Romagnani, University of Florence, Italy 

Chapter 13 Th17 cytokines in primary mucosal immunity
Jay K. Kolls and Shabaana A. Khader, Louisiana State University, USA 

Chapter 14 Th17 cells and IL-23 in gut inflammation
Giovanni Monteleone, Massimiliano Sarra, Francesco Pallone, Thomas T MacDonald, University Tor Vergata of Rome, Italy 

Chapter 15 The roles of IL-17A and IL-17F in mucosal infection and allergy
Harumichi Ishigame, Susumu Nakae, and Yoichiro Iwakura, University of Tokyo, Japan 

Chapter 16 Th17 cells in fungal infections
Teresa Zelante, Antonella De Luca and Luigina Romani, University of Perugia, Italy 

Chapter 17 IL-17 cells in organ transplantation rejection and tolerance
Julia Tsang, Ling Lu and Shuiping Jiang, Imperial College London, UK

Chapter 18 Th17 cells, proteins associated with Th17 polarization, and their role in graft-versus-host disease
Jonathan S Serody, Timothy P Moran, Bruce R Blazar, University of Minnesota, USA 

Chapter 19 Interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease: A tale of Yin and Yang
Xuebin Liu, Stewart Leung, Lei Fang, Xi Chen, Taylor Guo and Jingwu Zhang, GSK R&D China, China 

Chapter 20 The role of interleukin-17 in systemic lupus erythematosus
José C. Crispín, Vasileios C. Kyttaris, George C. Tsokos, Harvard University, USA 

Chapter 21 IL-17 in B cell biology and systemic lupus erythematosus
Agnès Doreau-Bastid, Jeremy Bastid, Alexandre Belot, Jean-François Eliaou and Nathalie Bonnefoy-Berard, INSERM, France 

Chapter 22 IL-17 and Th17 cells in human rheumatoid arthritis
Pierre Miossec, University of Lyon, France 

Chapter 23 The role of the IL-23 / Th17 immune pathway in the pathogenesis of arthritis
Erik Lubberts, University of Rotterdam, the Netherlands 

Chapter 24 The roles of IL-22 and its related family members in the pathogenesis of psoriasis
Patricia Valdez and Wenjun Ouyang, Genentech, USA 

Chapter 25 IL-23/Th17 pathway in psoriasis and inflammatory skin diseases
Kristine E. Nograles, Batya Davidovici and James G. Krueger, Rockefeller University, USA 

Chapter 26 Th17 cells in the tumor microenvironment
Cailin Moira Wilke and Weiping Zou, University of Michigan, USA 

Chapter 27 IL-17-producing NKT cells in airway inflammation
Dale T Umetsu, and Rosemarie H. DeKruyff, Harvard University, USA 

28 IL-17-producing gd T cells in autoimmune disease
Rebecca L. O’Brien, Philip L. Simonian, Yafei Huang, Christina L. Roark, Niyun Jin, M. Kemal Aydintug, Jennifer L. Chain, Andrew P. Fontenot, and Willi K. Born, National Jewish Health, USA

About this Book

“About 25 years ago, Mosmann & Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation, which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation.  

However, TH1 / TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset of T cells called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing autoimmune tissue inflammation.

The discovery of TH17 cells has expanded the TH1 / TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector T cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and autoimmune disease settings.”

- From Chapter One by Vijay K. Kuchroo, Harvard University, USA

“The recent identified Interleukin 17 (IL-17) cytokine family contributes to immunity to infectious diseases and chronic inflammatory diseases. Further studies on the regulation and function of this important cytokine family may provide better understanding on the roles of the IL-17 family in immune-mediated diseases; such knowledge may lead to the development of immunotherapeutic strategies for treatment of several inflammatory diseases.”

- From Chapter Two by Chen Dong, University of Texas and MD Anderson Cancer Center, USA

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